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Research

Research

Freeman MP1, Fava M, Lake J, Trivedi MH, Wisner KL, Mischoulon D. “Complementary and alternative medicine in major depressive disorder: the American Psychiatric Association Task Force report.” J Clin Psychiatry. 2010 Jun;71(6):669-81.

Maurizio Fava, M. “Using Complementary and Alternative Medicines for Depression” J Clin Psychiatry 2010;71[9]

Richard Nahas MD CCFP Osmaan Sheikh MD “Complementary and alternative medicine for the treatment of major depressive disorder” Canadian Family Physician VOL 57: JUNE 201

Parker G, Brotchie H. “D” for depression: any role for vitamin D? “Food for Thought” II. Acta Psychiatr Scand 2011;124(4):243-249.

Holick MF. “Vitamin D deficiency.” N Engl J Med 2007;357(3):266-281.

Hoogendijk WJ, Lips P, Dik MG, Deeg DJ, Beekman AT, Penninx BW. “Depression is associated with decreased 25-hydroxyvitamin D and increased parathyroid hormone levels in older adults.” Arch Gen Psychiatry 2008;65(5):508-512.

Pan A, Lu L, Franco OH, Yu Z, Li H, Lin X. “Association between depressive symptoms and 25-hydroxyvitamin D in middle-aged and elderly Chinese.” J Affect Disord 2009;118(1-3):240-243.

Milaneschi Y, Shardell M, Corsi AM, et al. “Serum 25-hydroxyvitamin D and depressive symptoms in older women and men” J Clin Endocrinol Metab 2010;95(7):3225-3233.

Jorde R, Sneve M, Figenschau Y, Svartberg J, Waterloo K. “Effects of vitamin D supplementation on symptoms of depression in overweight and obese subjects: randomized double blind trial.” J Intern Med 2008;264(6):599-609.

Bottiglieri, T. “Folate, vitamin B12 and neuropsychiatric disorders.” Nutr. Rev., 54:382-390

Crellin, R., Bottiglieri, T., and Reynolds, E.H. “Folates and psychiatric disorders.” Drugs, 45:623-636

Fava, M., et al. “Folate, B12, and homocysteine in major depression.” Am. J. Psychiatry, 154:426-428

Gilbody S, Lewis S, Lightfoot T “Methylenetetrahydrofolate reductase (MTHFR) genetic polymorphisms and psychiatric disorders: A HuGE review.” Am J Epidemiol 2007;165:1– 13.

Gilbody S, Lightfoot T, Sheldon T “Is low folate a risk factor for depression? A metaanalysis and exploration of heterogeneity.” J Epidemiol Community Health 2007;61:631–637.

Bender DA. “Non-nutritional uses of vitamin B6.” Br J Nutr. 1999;81(1):7-20

Kleijnen J, Ter Riet G, Knipschild P. “Vitamin B6 in the treatment of the premenstrual syndrome--a review.” Br J Obstet Gynaecol. 1990;97(9):847-852.

Wyatt KM, Dimmock PW, Jones PW, Shaughn O'Brien PM. “Efficacy of vitamin B-6 in the treatment of premenstrual syndrome: Systematic review.” Bmj. 1999;318(7195): 1375-1381.

Williams AL, Cotter A, Sabina A, Girard C, Goodman J, Katz DL. “The role for vitamin B-6 as treatment for depression: a Systematic review.” Fam Pract. 2005;22(5):532-537.

Hutto BR. “Folate and cobalamin in psychiatric illness.” Compr Psychiatry. 1997;38(6): 305-314.

Penninx BW, Guralnik JM, Ferrucci L, Fried LP, Allen RH, Stabler SP. “Vitamin B(12) deficiency and depression in physically disabled older women: epidemiologic evidence from the Women's Health and Aging Study.” Am J Psychiatry. 2000;157(5):715-721.

Tiemeier H, van Tuijl HR, Hofman A, Meijer J, Kiliaan AJ, Breteler MM. “Vitamin B12, folate, and homocysteine in depression: the Rotterdam Study.” Am J Psychiatry. 2002;159(12):2099-2101.

Amr M, El-Mogy A, Shams T, Vieira K, Lakhan SE. “Efficacy of vitamin C as an adjunct to fluoxetine therapy in pediatric major depressive disorder: a randomized, double-blind, placebo-controlled pilot study” Nutr J. 2013 Mar 9;12:31

Mazloom Z, Ekramzadeh M, Hejazi N. “Efficacy of supplementary vitamins C and E on anxiety, depression and stress in type 2 diabetic patients: a randomized, single-blind, placebo-controlled trial” Pak J Biol Sci. 2013 Nov 15;16(22):1597-600

Cooper JR. “The role of ascorbic acid in the oxidation of tryptophan to 5- hydroxytryptophan.” Ann NY Acad Sci 1961;92:208-11.

Bressa GM. “S-adenosyl-l-methionine (SAMe) as antidepressant: meta-analysis of clinical studies.” Acta Neurol Scand Suppl. 1994;154:7-14.

Bell KM, Plon L, Bunney WE, Jr., Potkin SG. “S-adenosylmethionine treatment of depression: a controlled clinical trial.” Am J Psychiatry. 1988;145(9):1110-1114.

Delle Chiaie R, Pancheri P, Scapicchio P. “Efficacy and tolerability of oral and intramuscular S-adenosyl-L-methionine 1,4-butanedisulfonate (SAMe) in the treatment of major depression: comparison with imipramine in 2 multicenter studies.” Am J Clin Nutr. 2002;76(5):1172S-1176S.

Williams AL, Girard C, Jui D, Sabina A, Katz DL. “S-adenosylmethionine (SAMe) as treatment for depression: a Systematic review.” Clin Invest Med. 2005;28(3):132-139.

Papakostas GI, Mischoulon D, Shyu I, Alpert JE, Fava M “S-adenosyl methionine (SAMe) augmentation of serotonin reuptake inhibitors for antidepressant nonresponders with major depressive disorder: A double- blind, randomized clinical trial.” Am J Psychiatry 2010;167:942–948.

Nelson JC: S-adenosyl methionine (SAMe) augmentation in major depressive disorder.” Am J Psychiatry 2010;167:889–891.

Hibbeln JR. “Fish consumption and major depression.” Lancet. 1998;351(9110):1213.

Noaghiul S, Hibbeln JR. “Cross-national comparisons of seafood consumption and rates of bipolar disorders.” Am J Psychiatry. 2003;160(12):2222-2227.

Maes M, Christophe A, Delanghe J, Altamura C, Neels H, Meltzer HY. “Lowered omega3 polyunsaturated fatty acids in serum phospholipids and cholesteryl esters of depressed patients.” Psychiatry Res. 1999;85(3):275-291.

Peet M, Murphy B, Shay J, Horrobin D. “Depletion of omega-3 fatty acid levels in red blood cell membranes of depressive patients.” Biol Psychiatry. 1998;43(5):315-319.

Tiemeier H, van Tuijl HR, Hofman A, Kiliaan AJ, Breteler MM. “Plasma fatty acid composition and depression are associated in the elderly: the Rotterdam Study.” Am J Clin Nutr. 2003;78(1):40-46.

Mamalakis G, Tornaritis M, Kafatos A. “Depression and adipose essential polyunsaturated fatty acids. Prostaglandins Leukot Essent Fatty Acids.” 2002;67(5): 311-318.

Locke CA, Stoll AL. “Omega-3 fatty acids in major depression.” World Rev Nutr Diet. 2001;89:173-185.

Silvers KM, Woolley CC, Hamilton FC, Watts PM, Watson RA. “Randomised doubleblind placebo-controlled trial of fish oil in the treatment of depression. Prostaglandins Leukot Essent Fatty Acids.” 2005;72(3):211-218.

Grenyer BF, Crowe T, Meyer B, et al. “Fish oil supplementation in the treatment of major depression: a randomised double-blind placebo-controlled trial.” Prog Neuropsychopharmacol Biol Psychiatry. 2007;31(7):1393-1396.

Marangell LB, Martinez JM, Zboyan HA, Kertz B, Kim HF, Puryear LJ. “A double-blind, placebo-controlled study of the omega-3 fatty acid docosahexaenoic acid in the treatment of major depression.” Am J Psychiatry. 2003;160(5):996-998.

Su KP, Huang SY, Chiu CC, Shen WW. “Omega-3 fatty acids in major depressive disorder. A preliminary double-blind, placebo-controlled trial.” Eur Neuropsychopharmacol. 2003;13(4):267-271.

Nemets H, Nemets B, Apter A, Bracha Z, Belmaker RH. “Omega-3 treatment of childhood depression: a controlled, double-blind pilot study.” Am J Psychiatry. 2006;163(6):1098-1100.

Stoll AL, Severus WE, Freeman MP, et al. “Omega 3 fatty acids in bipolar disorder: a preliminary double-blind, placebo-controlled trial”. Arch Gen Psychiatry. 1999;56(5): 407-412.

Keck PE, Jr., Mintz J, McElroy SL, et al. “Double-blind, randomized, placebo-controlled trials of ethyl-eicosapentanoate in the treatment of bipolar depression and rapid cycling bipolar disorder.” Biol Psychiatry. 2006;60(9):1020-1022.

Osher Y, Bersudsky Y, Belmaker RH. “Omega-3 eicosapentaenoic acid in bipolar depression: report of a small open-label study.” J Clin Psychiatry. 2005;66(6):726-729.

Frangou S, Lewis M, McCrone P. “Efficacy of ethyl-eicosapentaenoic acid in bipolar depression: randomised double-blind placebo-controlled study.” Br J Psychiatry. 2006;188:46-50.

Lin PY, Su KP. “A meta-analytic review of double-blind, placebo-controlled trials of antidepressant efficacy of omega-3 fatty acids.” J Clin Psychiatry. 2007;68(7): 1056-1061.

Freeman MP, Hibbeln JR, Wisner KL, et al. “Omega-3 fatty acids: evidence basis for treatment and future research in psychiatry.” J Clin Psychiatry. 2006;67(12):1954-1967.

Appleton KM, Hayward RC, Gunnell D, et al. “Effects of n-3 long-chain polyunsaturated fatty acids on depressed mood: Systematic review of published trials.” Am J Clin Nutr. 2006;84(6):1308-1316.

Oken E, Belfort MB: “Fish, fish oil, and pregnancy.” JAMA 2010;304:1717–1718.

Sublette ME, Ellis SP, Geant AL, Mann JJ “Meta-analysis: Effects of eicosapentaenoic acid in clinical trials in depression.” J Clin Psychiatry, in press.

Makrides M, Gibson RA, McPhee AJ, Yelland L, Quinlivan J, Ryan P “the DOMInO Investigative Team: Effect of DHA supplementation during pregnancy on maternal depression and neurodevelopment of young children: A randomized controlled trial.” JAMA 2010;304:1675–1683.

Freeman MP, Rapaport MH: “Omega-3 fatty acids and depression: From cellular mechanisms to clinical care.” J Clin Psychiatry, 2011 Feb;72(2):258-9.

Kiecolt-Glaser,Janice,K; Belury,Martha,A; Andridge,Rebecca; Malarkey,William,B; Glaser,Ronald. "Omega-3 supplementation lowers inflammation and anxiety in medical students: A randomized controlled trial." BRAIN BEHAVIOR AND IMMUNITY. Vol. 25, no. 8. (November 2011.): 1725-1734.

Hibbeln JR “Fish consumption and major depression.” Lancet 1998;351:1213.

Stoll AL, Severus WE, Freeman MP, Rueter S, Zboyan HA, Diamond E, Cress KK, Marangell LB “Omega 3 fatty acids in bipolar disorder: A preliminary double-blind, placebo- controlled trial.” Arch Gen Psychiatry 1999;56:407–412.

Nidecker A “Fish oil fatty acids may soothe some disorders.” Clin Psychiatry News November 1998, p 10.

Puri BK, Counsell SJ, Richardson AJ, Horrobin DF “Eicosapentaenoic acid in treatmentresistant depression.” Arch Gen Psychiatry 2002;59:91–92.

Alan J. Gelenberg, MD “EPA FOR RESISTANT DEPRESSION” Biological Therapies in Psychiatry. SEPTEMBER 2002 VOL 25 NO 9

Smith KJ, et al. “Longitudinal associations between fish consumption and depression in young adults” American Journal of Epidemiology, 04/18/2014

Freeman MP “Omega-3 fatty acids in psychiatry: A review.” Ann Clin Psychiatry 2000;12:159-165.

Tanskanen A, Hibbeln JR, Tuomilehto J, Uutela A, Haukkala A, Viinamäki H, Lehtonen J, Vartiainen E “Fish consumption and depressive symptoms in the general population in Finland.” Psychiatr Serv 2001;52:529-531.

Timonen M, Horrobin D, Jokelainen J, Laitinen J, Herva A, Räsänen P “Fish consumption and depression: The Northern Finland 1966 birth cohort study.” J Affect Disord 2004;82:447-452.